|
KMID : 1130620080040020067
|
|
Journal of Clinical Neurology
2008 Volume.4 No. 2 p.67 ~ p.74
|
|
|
Intracranial Hemodynamic Changes During Adult Moyamoya Disease Progression
|
|
Kwag Hyun-Jeong
Kim Jei
Kim Dae-Hyun
Lee Suk-Hoon
Jeong Dong-Wook
|
|
|
Abstract
|
|
|
Background and purpose: This study evaluated the changes in blood flow velocity in the anterior and posterior
intracranial circulations according to the progression of moyamoya disease in adult patients.
Methods: We evaluated Suzuki’s angiographic stage and mean blood flow velocity (MBFV) changes in intracranial vessels from both sides in 19 adult moyamoya patients. We then analyzed the linearity of MBFV changes from early to late moyamoya stages in each intracranial vessel using piecewise linear regression models.
Results: The MBFV in the middle cerebral artery, terminal internal carotid artery, and anterior cerebral artery
increased non linearly until stage III, and then decreased progressively up to stage VI. The ophthalmic artery also
showed nonlinear velocity changes, with an increase in MBFV up to stage IV, followed by a decrease in MBFV up
to stage VI. The MBFV of the basilar artery increased linearly from a normal velocity at an early moyamoya stage
to a stenotic velocity at a late stage. There was no statistically significant regression model for the relationship
between the MBFV in the posterior cerebral artery and moyamoya stage.
Conclusions: The nonlinear and/or linear MBFV changes associated with variable intracranial vessels might be
useful in initial and follow-up evaluations of different stages of moyamoya disease.
|
|
|
KEYWORD
|
|
|
Moyamoya disease, Transcranial Doppler, Cerebral blood flow
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
   
|